HOXA4Provides Stronger Engraftment Potential to Short-Term Repopulating Cells ThanHOXB4
نویسندگان
چکیده
منابع مشابه
Increased Engraftment of Human Short Term Repopulating Hematopoietic Cells in NOD/SCID/IL2rγnull Mice by Lentiviral Expression of NUP98-HOXA10HD
Techniques to expand human hematopoietic stem cells ex-vivo could be beneficial to the fields of clinical hematopoietic stem cell transplantation and gene therapy targeted at hematopoietic stem cells. NUP98-HOXA10HD is a relatively newly discovered fusion gene that in mouse transplant experiments has been shown to increase numbers of hematopoietic stem cells. We evaluated whether this fusion ge...
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In the adult mouse the bone marrow serves as the major site for blood cell production and development. The large majority of the cells present in the bone marrow are relatively mature and derived from a small proportion designated as hematopoietic stem cells. These cells are capable of developing into all mature blood cell types and have the capacity of serf renewal. Hematopoietic stem cells re...
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We have previously demonstrated that we could separate long-term repopulating stem cells from cells that provided radioprotection (short-term repopulating cells) on the basis of size and suggested that this might be due to the quiescent nature of long-term repopulating cells. To further define the activity of these populations, we used a dye (PKH26), which incorporates into the membrane of cell...
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Long-term hematopoietic stem cells (LT-HSC) and short-term hematopoietic stem cells (ST-HSC) have been characterized as having markedly different in vivo repopulation, but similar in vitro growth in liquid culture. These differences could be due to differences in marrow homing. We evaluated this by comparing results when purified ST-HSC and LT-HSC were administered to irradiated mice by three d...
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ژورنال
عنوان ژورنال: Stem Cells and Development
سال: 2015
ISSN: 1547-3287,1557-8534
DOI: 10.1089/scd.2015.0063